Thursday, April 1, 2021

Specialized pro-resolving mediators reduce pro-nociceptive inflammatory mediator production in models of localized provoked vulvodynia

Vulvodynia afflicts 9-18% of women during their lifetime18, 32-34, 58, 67. Most patients suffer from localized provoked vulvodynia (LPV), which causes severe and lasting pain with touch to the vestibule, the vulvar tissue immediately surrounding the vaginal opening32, 67. Outer dermal portions of the vulva (external vulva), although only a few centimeters away, are relatively pain-free, while light touch to the mucocutaneous vestibule can result in lasting pain (allodynia)18, 26-28. This impairs a woman's ability to engage in sexual intercourse, use a tampon, or even walk18, 36, 51, 58, 64, resulting in a substantial decline in quality of life7, 8.

from The Journal of Pain https://ift.tt/3wllhZA
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