Differential activation of colonic afferents and dorsal horn neurons underlie stress-induced and comorbid visceral hypersensitivity in female rats

Chronic pain is a major health problem affecting 50-100 million people in the United States 30. Ten chronic pain conditions including irritable bowel syndrome (IBS) and temporomandibular disorder (TMD) are collectively known as Chronic Overlapping Pain Conditions and have minimal basis in underlying injury or disease 38, 61. One characteristic that sets these conditions apart is the propensity to overlap; having one condition significantly increases the odds of having multiple conditions 14, 54, 64, 65.

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