Tuesday, August 31, 2021

Mirror therapy for phantom limb pain in moderate intellectual disability. A case report

Abstract

Background

Phantom limb pain (PLP) is a common problem after limb amputation. There is mounting evidence supporting the use of mirror therapy (MT) in the treatment of individuals with PLP. However, there is no research studying the effects of MT on PLP in individuals with intellectual developmental disorders (IDD). The aim of this study was to increase our understanding of MT when used with adults with IDD and PLP through a case study approach.

Methods

Here, we describe the use of MT with a 53-year-old female with moderate IDD and PLP, related to her left leg being amputated after ulcer complications. The study followed an A-B-A-B design (baseline - treatment - withdrawal of treatment - re-introduction of treatment), lasting two years, which included a long-term follow-up.

Results

The data showed that the PLP sensation decreased after the MT treatment, with a raw change of 3.92 points and a 48% decrease in mean pain intensity ratings from pre- to post-treatment.

Conclusions

This is a unique case-report on the use of MT with an individual with IDD suffering from PLP. The findings show that MT helped to significantly reduce the intensity of the PLP in this patient.



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Temporal changes in pain processing after whiplash injury, based on Quantitative Sensory Testing: a systematic review

ABSTRACT

Background and Objective

After whiplash injury, some patients develop chronic Whiplash Associated Disorders. The exact pathophysiology of this chronification is still unclear and more knowledge is needed regarding the different post-injury phases. Therefore, studies were searched that examined temporal changes in pain processing, measured by Quantitative Sensory Testing (QST).

Databases and Data Treatment

This systematic review searched three electronic databases (Medline, Web of Science, and Embase) for articles meeting the eligibility requirements. Risk of bias was assessed according to a modified Newcastle-Ottawa Scale.

Results

The twelve included studies presented moderate to good methodological quality. These studies showed altered pain processing within the first month after injury and normalization within three months in 59 to 78% of the patients. After three months, recovery stagnates during the following years. Thermal and widespread mechanical hyperalgesia occur already in the acute phase, but only in eventually non-recovered patients.

Conclusions

Differences in pain processing between recovering and non-recovering patients can be observed already in the acute phase. Early screening for signs of altered pain processing can identify patients with high risk for chronification. These insights in temporal changes show the importance of rehabilitation in the acute phase. Future research should target to develop a standardized (bed-site) QST protocol and collect normative data which could, in relation with self-reported pain parameters, allow clinicians to identify the risk for chronification.



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Mirror therapy for phantom limb pain in moderate intellectual disability. A case report

Abstract

Background

Phantom limb pain (PLP) is a common problem after limb amputation. There is mounting evidence supporting the use of mirror therapy (MT) in the treatment of individuals with PLP. However, there is no research studying the effects of MT on PLP in individuals with intellectual developmental disorders (IDD). The aim of this study was to increase our understanding of MT when used with adults with IDD and PLP through a case study approach.

Methods

Here, we describe the use of MT with a 53-year-old female with moderate IDD and PLP, related to her left leg being amputated after ulcer complications. The study followed an A-B-A-B design (baseline - treatment - withdrawal of treatment - re-introduction of treatment), lasting two years, which included a long-term follow-up.

Results

The data showed that the PLP sensation decreased after the MT treatment, with a raw change of 3.92 points and a 48% decrease in mean pain intensity ratings from pre- to post-treatment.

Conclusions

This is a unique case-report on the use of MT with an individual with IDD suffering from PLP. The findings show that MT helped to significantly reduce the intensity of the PLP in this patient.



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Temporal changes in pain processing after whiplash injury, based on Quantitative Sensory Testing: a systematic review

ABSTRACT

Background and Objective

After whiplash injury, some patients develop chronic Whiplash Associated Disorders. The exact pathophysiology of this chronification is still unclear and more knowledge is needed regarding the different post-injury phases. Therefore, studies were searched that examined temporal changes in pain processing, measured by Quantitative Sensory Testing (QST).

Databases and Data Treatment

This systematic review searched three electronic databases (Medline, Web of Science, and Embase) for articles meeting the eligibility requirements. Risk of bias was assessed according to a modified Newcastle-Ottawa Scale.

Results

The twelve included studies presented moderate to good methodological quality. These studies showed altered pain processing within the first month after injury and normalization within three months in 59 to 78% of the patients. After three months, recovery stagnates during the following years. Thermal and widespread mechanical hyperalgesia occur already in the acute phase, but only in eventually non-recovered patients.

Conclusions

Differences in pain processing between recovering and non-recovering patients can be observed already in the acute phase. Early screening for signs of altered pain processing can identify patients with high risk for chronification. These insights in temporal changes show the importance of rehabilitation in the acute phase. Future research should target to develop a standardized (bed-site) QST protocol and collect normative data which could, in relation with self-reported pain parameters, allow clinicians to identify the risk for chronification.



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Sunday, August 29, 2021

Commentary on “The role of psychological flexibility, perceived injustice, and body‐image in Vulvodynia: a longitudinal study" by Chisari et al.

Abstract

This journal recently published a paper by Chisari et al., entitled “The role of psychological flexibility, perceived injustice, and body-image in Vulvodynia: a longitudinal study” (Chisari, Budhraja, et al., 2021). The study found that committed action positively predicted depression at 3 months and pain acceptance positively predicted pain interference at 3 months. Neither present moment awareness, perceived injustice, nor body exposure anxiety and avoidance during sexual activities were significant predictors of any outcome measures. Research into psychological factors in vulvodynia is lacking (Chisari, Monajemi, Scott, Moss-Morris, & McCracken, 2021), and exploration of the psychological flexibility (PF) model is a novel idea. Given that the PF model is a newer concept in the wider pain field, it is important to consider the strengths and weaknesses of the model in its application to women with vulvodynia.



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Saturday, August 28, 2021

Effectiveness of Mirror Therapy for Phantom Limb Pain: A Systematic Review and Meta-Analysis

Publication date: Available online 28 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Hui-Min Xie, Ke-Xue Zhang, Shuo Wang, Ning Wang, Na Wang, Xia Li, Li-Ping Huang



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Effectiveness of Mirror Therapy for Phantom Limb Pain: A Systematic Review and Meta-Analysis

Publication date: Available online 28 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Hui-Min Xie, Ke-Xue Zhang, Shuo Wang, Ning Wang, Na Wang, Xia Li, Li-Ping Huang



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Effectiveness of Mirror Therapy for Phantom Limb Pain: A Systematic Review and Meta-Analysis

Publication date: Available online 28 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Hui-Min Xie, Ke-Xue Zhang, Shuo Wang, Ning Wang, Na Wang, Xia Li, Li-Ping Huang



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Effectiveness of Mirror Therapy for Phantom Limb Pain: A Systematic Review and Meta-Analysis

Publication date: Available online 28 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Hui-Min Xie, Ke-Xue Zhang, Shuo Wang, Ning Wang, Na Wang, Xia Li, Li-Ping Huang



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Effectiveness of Mirror Therapy for Phantom Limb Pain: A Systematic Review and Meta-Analysis

Publication date: Available online 28 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Hui-Min Xie, Ke-Xue Zhang, Shuo Wang, Ning Wang, Na Wang, Xia Li, Li-Ping Huang



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Effectiveness of Mirror Therapy for Phantom Limb Pain: A Systematic Review and Meta-Analysis

Publication date: Available online 28 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Hui-Min Xie, Ke-Xue Zhang, Shuo Wang, Ning Wang, Na Wang, Xia Li, Li-Ping Huang



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Effectiveness of Mirror Therapy for Phantom Limb Pain: A Systematic Review and Meta-Analysis

Publication date: Available online 28 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Hui-Min Xie, Ke-Xue Zhang, Shuo Wang, Ning Wang, Na Wang, Xia Li, Li-Ping Huang



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Effectiveness of Mirror Therapy for Phantom Limb Pain: A Systematic Review and Meta-Analysis

Publication date: Available online 28 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Hui-Min Xie, Ke-Xue Zhang, Shuo Wang, Ning Wang, Na Wang, Xia Li, Li-Ping Huang



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Effectiveness of Mirror Therapy for Phantom Limb Pain: A Systematic Review and Meta-Analysis

Publication date: Available online 28 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Hui-Min Xie, Ke-Xue Zhang, Shuo Wang, Ning Wang, Na Wang, Xia Li, Li-Ping Huang



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Effectiveness of Mirror Therapy for Phantom Limb Pain: A Systematic Review and Meta-Analysis

Publication date: Available online 28 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Hui-Min Xie, Ke-Xue Zhang, Shuo Wang, Ning Wang, Na Wang, Xia Li, Li-Ping Huang



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Effectiveness of Mirror Therapy for Phantom Limb Pain: A Systematic Review and Meta-Analysis

Publication date: Available online 28 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Hui-Min Xie, Ke-Xue Zhang, Shuo Wang, Ning Wang, Na Wang, Xia Li, Li-Ping Huang



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Friday, August 27, 2021

How do fluctuations in pain, fatigue, anxiety, depressed mood and perceived cognitive function relate to same-day social participation in individuals with spinal cord injury?

Publication date: Available online 27 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Duygu Kuzu, Jonathan P. Troost, Noelle E. Carlozzi, Dawn M. Ehde, Ivan R. Molton, Anna L. Kratz



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How do fluctuations in pain, fatigue, anxiety, depressed mood and perceived cognitive function relate to same-day social participation in individuals with spinal cord injury?

Publication date: Available online 27 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Duygu Kuzu, Jonathan P. Troost, Noelle E. Carlozzi, Dawn M. Ehde, Ivan R. Molton, Anna L. Kratz



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How do fluctuations in pain, fatigue, anxiety, depressed mood and perceived cognitive function relate to same-day social participation in individuals with spinal cord injury?

Publication date: Available online 27 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Duygu Kuzu, Jonathan P. Troost, Noelle E. Carlozzi, Dawn M. Ehde, Ivan R. Molton, Anna L. Kratz



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How do fluctuations in pain, fatigue, anxiety, depressed mood and perceived cognitive function relate to same-day social participation in individuals with spinal cord injury?

Publication date: Available online 27 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Duygu Kuzu, Jonathan P. Troost, Noelle E. Carlozzi, Dawn M. Ehde, Ivan R. Molton, Anna L. Kratz



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How do fluctuations in pain, fatigue, anxiety, depressed mood and perceived cognitive function relate to same-day social participation in individuals with spinal cord injury?

Publication date: Available online 27 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Duygu Kuzu, Jonathan P. Troost, Noelle E. Carlozzi, Dawn M. Ehde, Ivan R. Molton, Anna L. Kratz



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How do fluctuations in pain, fatigue, anxiety, depressed mood and perceived cognitive function relate to same-day social participation in individuals with spinal cord injury?

Publication date: Available online 27 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Duygu Kuzu, Jonathan P. Troost, Noelle E. Carlozzi, Dawn M. Ehde, Ivan R. Molton, Anna L. Kratz



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How do fluctuations in pain, fatigue, anxiety, depressed mood and perceived cognitive function relate to same-day social participation in individuals with spinal cord injury?

Publication date: Available online 27 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Duygu Kuzu, Jonathan P. Troost, Noelle E. Carlozzi, Dawn M. Ehde, Ivan R. Molton, Anna L. Kratz



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How do fluctuations in pain, fatigue, anxiety, depressed mood and perceived cognitive function relate to same-day social participation in individuals with spinal cord injury?

Publication date: Available online 27 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Duygu Kuzu, Jonathan P. Troost, Noelle E. Carlozzi, Dawn M. Ehde, Ivan R. Molton, Anna L. Kratz



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How do fluctuations in pain, fatigue, anxiety, depressed mood and perceived cognitive function relate to same-day social participation in individuals with spinal cord injury?

Publication date: Available online 27 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Duygu Kuzu, Jonathan P. Troost, Noelle E. Carlozzi, Dawn M. Ehde, Ivan R. Molton, Anna L. Kratz



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How do fluctuations in pain, fatigue, anxiety, depressed mood and perceived cognitive function relate to same-day social participation in individuals with spinal cord injury?

Publication date: Available online 27 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Duygu Kuzu, Jonathan P. Troost, Noelle E. Carlozzi, Dawn M. Ehde, Ivan R. Molton, Anna L. Kratz



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Intraoperative pain during Cesarean delivery: Incidence, risk factors and physician perception

Abstract

Background

Intraoperative pain is a possible complication of neuraxial anesthesia for Cesarean delivery. There is little information available about its incidence, risk factors and physician perception.

Methods

Parturients undergoing spinal anesthesia for elective Cesarean delivery were enrolled. Before surgery, parturients were asked about preoperative anxiety on a verbal numerical scale (VNS), anticipated analgesic requirement, postoperative pain levels, Spielberger STATE-TRAIT inventory index, Pain Catastrophizing Scale. After surgery, parturients were asked to answer questions (intraoperative VNS pain). The anesthesiologist and obstetrician were asked to fill out a questionnaire asking about perceived intraoperative pain. Influence of preoperative anxiety on intraoperative pain (yes/no) was assessed using logistic regression. Mc Fadden’s R2 was calculated. The agreement in physician perception of intraoperative pain with reported pain by the parturient was examined by calculating Cohen’s kappa and 95% Confidence Intervals (CI).

Results

We included 193 parturients in our analysis. Incidence of intraoperative pain was 11.9%. Median intraoperative VNS pain of parturients with pain was 4.0 (1st quartile 4.0; 3rd quartile 9.0). Preoperative anxiety was not a good predictor of intraoperative pain (p-value of b-coefficient= 0.43, Mc Fadden’s R2= 0.01). Including further preoperative variables did not result in a good prediction model. Cohen’s kappa between reported pain by parturient and by the obstetrician was 0.21 (95% CI; 0.01, 0.41) and by the anesthesiologist was 0.3 (95% CI; 0.12, 0.48).

Conclusions

We found a substantial incidence (11.9%) of intraoperative pain during Cesarean delivery. Preoperative anxiety did not predict intraoperative pain. Physicians did not accurately identify parturients’ intraoperative pain.



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Morning and evening salivary cortisol levels in patients with chronic widespread pain and those at high risk

Abstract

Background

Hypothalamic-Pituitary-Adrenal (HPA) axis dysregulation has been implicated in chronic widespread pain (CWP); the hallmark of fibromyalgia (FM). This is the first study to compare HPA axis changes in individuals with CWP and those at high risk of symptom development.

Methods

We sought to determine differences in morning and evening salivary cortisol levels in FM (n = 19), those at-risk (n = 20), and pain-free controls (n = 17). Risk factors included non-CWP pain, somatic symptoms, illness behaviour and sleep disturbance. We conducted the study in the absence of centrally-acting medication, to address limitations of previous research.

Results

Repeated measures ANOVA revealed significant main effects of group (p = 0.003), and time of day (p = 0.002), with no significant interaction. Cortisol levels were higher in FM (p = 0.027) and at-risk (p = 0.003) groups, compared to controls, but there was no significant difference between FM and at-risk groups. The main effect of group remained significant with sleep problems (p = 0.021), and life events (p = 0.007), but was not significant with anxiety (p = 0.076) or depression (p = 0.098) scores as covariates. With sleep problems as a covariate, cortisol levels remained significantly higher only in the at-risk group (p = 0.017).

Conclusions

This study indicates elevated salivary cortisol in FM and those at high risk, and identifies anxiety, depression, and sleep problems as potential contributing factors. The results shed light on the dynamic relationship between stress, mood and sleep disorders and the brain’s resilience to pain.



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Wednesday, August 25, 2021

Why severe sickle-cell pain has been neglected

Nature, Published online: 25 August 2021; doi:10.1038/d41586-021-02142-0

Pain in sickle-cell disease is poorly understood — and patients face both medical and socioeconomic problems when seeking delivery from discomfort.

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Saturday, August 21, 2021

Exercise therapy is effective for improvement in range of motion, function and pain in patients with frozen shoulder: a systematic review and meta-analysis

Publication date: Available online 21 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Michel GCAM Mertens, Lotte Meert, Filip Struyf, Ariane Schwank, Mira Meeus



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Exercise therapy is effective for improvement in range of motion, function and pain in patients with frozen shoulder: a systematic review and meta-analysis

Publication date: Available online 21 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Michel GCAM Mertens, Lotte Meert, Filip Struyf, Ariane Schwank, Mira Meeus



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Exercise therapy is effective for improvement in range of motion, function and pain in patients with frozen shoulder: a systematic review and meta-analysis

Publication date: Available online 21 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Michel GCAM Mertens, Lotte Meert, Filip Struyf, Ariane Schwank, Mira Meeus



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Exercise therapy is effective for improvement in range of motion, function and pain in patients with frozen shoulder: a systematic review and meta-analysis

Publication date: Available online 21 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Michel GCAM Mertens, Lotte Meert, Filip Struyf, Ariane Schwank, Mira Meeus



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Exercise therapy is effective for improvement in range of motion, function and pain in patients with frozen shoulder: a systematic review and meta-analysis

Publication date: Available online 21 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Michel GCAM Mertens, Lotte Meert, Filip Struyf, Ariane Schwank, Mira Meeus



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Exercise therapy is effective for improvement in range of motion, function and pain in patients with frozen shoulder: a systematic review and meta-analysis

Publication date: Available online 21 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Michel GCAM Mertens, Lotte Meert, Filip Struyf, Ariane Schwank, Mira Meeus



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Exercise therapy is effective for improvement in range of motion, function and pain in patients with frozen shoulder: a systematic review and meta-analysis

Publication date: Available online 21 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Michel GCAM Mertens, Lotte Meert, Filip Struyf, Ariane Schwank, Mira Meeus



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Exercise therapy is effective for improvement in range of motion, function and pain in patients with frozen shoulder: a systematic review and meta-analysis

Publication date: Available online 21 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Michel GCAM Mertens, Lotte Meert, Filip Struyf, Ariane Schwank, Mira Meeus



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Exercise therapy is effective for improvement in range of motion, function and pain in patients with frozen shoulder: a systematic review and meta-analysis

Publication date: Available online 21 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Michel GCAM Mertens, Lotte Meert, Filip Struyf, Ariane Schwank, Mira Meeus



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Exercise therapy is effective for improvement in range of motion, function and pain in patients with frozen shoulder: a systematic review and meta-analysis

Publication date: Available online 21 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Michel GCAM Mertens, Lotte Meert, Filip Struyf, Ariane Schwank, Mira Meeus



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Exercise therapy is effective for improvement in range of motion, function and pain in patients with frozen shoulder: a systematic review and meta-analysis

Publication date: Available online 21 August 2021

Source: Archives of Physical Medicine and Rehabilitation

Author(s): Michel GCAM Mertens, Lotte Meert, Filip Struyf, Ariane Schwank, Mira Meeus



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Tuesday, August 17, 2021

Effects of human variation on foot and ankle pain in rural Madagascar

Abstract

Objectives

Foot and ankle dysfunction in barefoot/minimally shod populations remains understudied. Although factors affecting musculoskeletal pain in Western populations are well-studied, little is known about how types of work, gender, and body shape influence bone and joint health in non-Western and minimally shod communities. This study examines the effect of human variation on locomotor disability in an agrarian community in Madagascar.

Materials and methods

Foot measurements were collected along with height, weight, age, and self-report data on daily activity and foot and ankle pain from 41 male and 48 female adults. A short form revised foot function index (FFI-R), that measures functional disability related to foot pain, was calculated. Raw and normalized foot measurements were compared by gender and used in a multiple linear regression model to determine predictors of FFI-R.

Results

Compared to men, women reported higher FFI-R scores (p = 0.014), spent more time on their feet (p = 0.019), and had higher BMIs (p = 0.0001). For their weight, women had significantly smaller and narrower feet than men. Bimalleolar breadth (p = 0.0005) and foot length (p = 0.0223) standardized by height, time spent on feet (p = 0.0102), ankle circumference standardized by weight (p = 0.0316), and age (p = 0.0090) were significant predictors of FFI-R score.

Discussion

Our findings suggest that human variation in anatomical and behavioral patterns serve as significant explanations for increased foot and ankle pain in women in this non-Western rural population. Foot and ankle pain were prevalent at similar levels to those in industrialized populations, indicating that research should continue to examine its effect on similar barefoot/minimally shod communities.



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Effects of human variation on foot and ankle pain in rural Madagascar

Abstract

Objectives

Foot and ankle dysfunction in barefoot/minimally shod populations remains understudied. Although factors affecting musculoskeletal pain in Western populations are well-studied, little is known about how types of work, gender, and body shape influence bone and joint health in non-Western and minimally shod communities. This study examines the effect of human variation on locomotor disability in an agrarian community in Madagascar.

Materials and methods

Foot measurements were collected along with height, weight, age, and self-report data on daily activity and foot and ankle pain from 41 male and 48 female adults. A short form revised foot function index (FFI-R), that measures functional disability related to foot pain, was calculated. Raw and normalized foot measurements were compared by gender and used in a multiple linear regression model to determine predictors of FFI-R.

Results

Compared to men, women reported higher FFI-R scores (p = 0.014), spent more time on their feet (p = 0.019), and had higher BMIs (p = 0.0001). For their weight, women had significantly smaller and narrower feet than men. Bimalleolar breadth (p = 0.0005) and foot length (p = 0.0223) standardized by height, time spent on feet (p = 0.0102), ankle circumference standardized by weight (p = 0.0316), and age (p = 0.0090) were significant predictors of FFI-R score.

Discussion

Our findings suggest that human variation in anatomical and behavioral patterns serve as significant explanations for increased foot and ankle pain in women in this non-Western rural population. Foot and ankle pain were prevalent at similar levels to those in industrialized populations, indicating that research should continue to examine its effect on similar barefoot/minimally shod communities.



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Monday, August 16, 2021

When one suffers less, all suffer less: individual pain ratings are more effective than group ratings in producing placebo hypoalgesia

Abstract

Background

Placebo hypoalgesia can be induced by observing a person (model) whose pain relief is the result of the use of an inert substance or procedure. This study examined whether verbal modeling, i.e. showing pain ratings provided by other people, is sufficient to induce placebo hypoalgesia.

Methods

Participants from the experimental groups were acquainted with pain ratings (presented on VASs) derived from a single person (groups 1 and 3) or a group of people (groups 2 and 4) that were allegedly subjected to the same painful procedure. The ratings of pain stimuli that were allegedly applied with placebo were lower than the ratings of stimuli applied without placebo. In two of the experimental groups (group 3 and 4), participants also watched a video recording showing individuals who allegedly provided pain ratings; however, they did not observe them undergoing pain stimulation. The control group did not undergo any manipulation. Then, the participants received a series of the same thermal pain stimuli that were applied either with or without placebo and rated their intensity.

Results

Placebo hypoalgesia was induced only in participants presented with pain ratings provided by a single person, regardless of whether this person was previously seen. However, the pain ratings presented to the participants generally decreased individual pain sensations, regardless of whether they came from a group of people or a single person.

Conclusions

Verbal modeling can produce placebo hypoalgesia and reduce pain sensations. It may be effectively used in clinical practice to modify patients’ responses to pain treatment.



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The effects of attentional and interpretation biases on later pain outcomes among younger and older adults: a prospective study

Abstract

Background

Studies examining the effect of biased cognitions on later pain outcomes have primarily focused on attentional biases, leaving the role of interpretation biases largely unexplored. Also, few studies have examined pain-related cognitive biases in elderly persons. The current study aims to fill these research gaps.

Methods

Younger and older adults with and without chronic pain (N = 126) completed an interpretation bias task and a free-viewing task of injury and neutral scenes at baseline. Participants’ pain intensity and disability were assessed at baseline and at a six-month follow-up. A machine-learning data-driven approach to analysing eye movement data was adopted.

Results

Eye movement analyses revealed two common attentional pattern subgroups for scene-viewing: an “explorative” group and a “focused” group. At baseline, participants with chronic pain endorsed more injury-/illness-related interpretations compared to pain-free controls, but they did not differ in eye movements on scene images. Older adults interpreted illness-related scenarios more negatively compared to younger adults, but there was also no difference in eye movements between age groups. Moreover, negative interpretation biases were associated with baseline but not follow-up pain disability, whereas a focused gaze tendency for injury scenes was associated with follow-up but not baseline pain disability. Additionally, there was an indirect effect of interpretation biases on pain disability six months later through attentional bias for pain-related images.

Conclusions

The present study provided evidence for pain status and age group differences in injury-/illness-related interpretation biases. Results also revealed distinct roles of interpretation and attentional biases in pain chronicity.



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When one suffers less, all suffer less: individual pain ratings are more effective than group ratings in producing placebo hypoalgesia

Abstract

Background

Placebo hypoalgesia can be induced by observing a person (model) whose pain relief is the result of the use of an inert substance or procedure. This study examined whether verbal modeling, i.e. showing pain ratings provided by other people, is sufficient to induce placebo hypoalgesia.

Methods

Participants from the experimental groups were acquainted with pain ratings (presented on VASs) derived from a single person (groups 1 and 3) or a group of people (groups 2 and 4) that were allegedly subjected to the same painful procedure. The ratings of pain stimuli that were allegedly applied with placebo were lower than the ratings of stimuli applied without placebo. In two of the experimental groups (group 3 and 4), participants also watched a video recording showing individuals who allegedly provided pain ratings; however, they did not observe them undergoing pain stimulation. The control group did not undergo any manipulation. Then, the participants received a series of the same thermal pain stimuli that were applied either with or without placebo and rated their intensity.

Results

Placebo hypoalgesia was induced only in participants presented with pain ratings provided by a single person, regardless of whether this person was previously seen. However, the pain ratings presented to the participants generally decreased individual pain sensations, regardless of whether they came from a group of people or a single person.

Conclusions

Verbal modeling can produce placebo hypoalgesia and reduce pain sensations. It may be effectively used in clinical practice to modify patients’ responses to pain treatment.



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The effects of attentional and interpretation biases on later pain outcomes among younger and older adults: a prospective study

Abstract

Background

Studies examining the effect of biased cognitions on later pain outcomes have primarily focused on attentional biases, leaving the role of interpretation biases largely unexplored. Also, few studies have examined pain-related cognitive biases in elderly persons. The current study aims to fill these research gaps.

Methods

Younger and older adults with and without chronic pain (N = 126) completed an interpretation bias task and a free-viewing task of injury and neutral scenes at baseline. Participants’ pain intensity and disability were assessed at baseline and at a six-month follow-up. A machine-learning data-driven approach to analysing eye movement data was adopted.

Results

Eye movement analyses revealed two common attentional pattern subgroups for scene-viewing: an “explorative” group and a “focused” group. At baseline, participants with chronic pain endorsed more injury-/illness-related interpretations compared to pain-free controls, but they did not differ in eye movements on scene images. Older adults interpreted illness-related scenarios more negatively compared to younger adults, but there was also no difference in eye movements between age groups. Moreover, negative interpretation biases were associated with baseline but not follow-up pain disability, whereas a focused gaze tendency for injury scenes was associated with follow-up but not baseline pain disability. Additionally, there was an indirect effect of interpretation biases on pain disability six months later through attentional bias for pain-related images.

Conclusions

The present study provided evidence for pain status and age group differences in injury-/illness-related interpretation biases. Results also revealed distinct roles of interpretation and attentional biases in pain chronicity.



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Friday, August 13, 2021

William Ian Campbell

My father, William Ian Campbell, was a recent president of the British Pain Society. He was one of few who worked in anaesthetics, intensive care medicine, and (most of all) chronic pain...


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Wednesday, August 11, 2021

Mechanisms of Change in Acceptance and Commitment Therapy for Primary Headaches

Abstract

Background

Despite the demonstrated effectiveness of behavioural headache interventions, it is not yet known which intervention processes account for treatment responses. Acceptance and commitment therapy (ACT), an emerging behavioural intervention for headaches, proposes psychological flexibility (PF) processes as the mechanisms via which intervention change occurs. This is the first study examining these process of change variables on headache-related disability and quality of life (treatment outcome).

Methods

Data originated from a Randomized Clinical Trial evaluating the efficacy of ACT for primary headaches. Ninety-four individuals with primary headaches (M=43 yrs; 84% females; M headache frequency/month=9.30) were randomized to either an ACT-based or a Wait-list control group (N=47 in each). Participants completed questionnaires related to their headache experiences and PF processes at pre- (T1), post-treatment (T2), and 3-month follow-up (T3).

Results

Following a bootstrapped cross product of coefficients approach, results demonstrated mediating effects of headache acceptance, cognitive defusion, avoidance of headache, and mindfulness in the ACT group compared to control on parameters of headache-related disability and quality of life at post and 3-month follow-ups.

Conclusions

These findings demonstrate that changes in certain PF processes lower disability and improve quality of life in headache sufferers, supporting that ACT works via its proposed mechanisms of change. Interventions for headache management may be optimized if they target increases in headache acceptance, defusion from thoughts, and mindfulness.



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Tuesday, August 10, 2021

Cognitive agency in music interventions: Increased perceived control of music predicts increased pain tolerance

Abstract

Background

Self-selected music is consistently found to be the strongest predictor for successful music listening interventions in pain management contexts, but the specific cognitive mechanisms that mediate these effects are currently unknown.

Objectives

The aim of this study was to isolate the role of cognitive agency on pain tolerance in music listening interventions, independently from parallel effects related to enjoyment. Additionally, the study examines the role of intramusical features and individual attributes related to musical engagement.

Methods

Fifty-two participants completed a repeated measures experiment, which involved listening to six different pieces of music while completing the cold pressor task. Cognitive agency was operationalized by giving participants different degrees of perceived control over the music selection, when in fact it was pre-determined by the experimenter.

Results

A generalized linear mixed model was used to analyse the impact of perceived choice and intramusical features on pain tolerance measured in terms of duration on the cold pressor task, pain intensity and pain unpleasantness. Increased levels of perceived choice predicted increases in pain tolerance when enjoyment was accounted for. Individual levels of trait empathy and sophisticated emotional engagement with music also contributed to the effects. Intramusical features did not predict increases in pain tolerance.

Conclusions

This study demonstrates that the reason self-selected music is particularly effective in reducing pain is related to the act of making a choice over the music itself. This study provides support for the cognitive vitality model and emphasizes the importance of giving people as much control as possible in music interventions.

Significance

This study identifies that the act of selecting music contributes to increases in pain tolerance in parallel with the independent factor of enjoyment. This provides support for the role of cognitive agency in mediating the analgesic effects of music interventions, which suggests that people should be given as much control as possible in music interventions. Additionally, this study identifies specific individual attributes related to emotional engagement and empathy that amplify the effect of cognitive agency.



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Pain referral area is reduced by remote pain

Abstract

Background

Endogenous pain inhibitory mechanisms are known to reduce pain intensity, but whether they influence the size and distribution of pain referral is unclear. This study aimed to determine if referred pain is reduced by applying a remote, conditioning painful stimulus.

Methods

Twenty-four healthy men participated in this randomized, crossover study with a control and conditioning session. Referred pain was induced from the infraspinatus muscle (dominant side) by a painful pressure for 60 s. When applying pressure, the intensity was adjusted to a local pain intensity of 7/10 on a numerical rating scale. In the conditioning session, tonic painful pressure was simultaneously applied to the non-dominant leg during induction of referred pain. The area of referred pain was drawn onto a digital body chart and size extracted for data analysis.

Results

For the total group and in a subgroup with distinct patterns of referred pain (n = 15/24), the pain area perceived in the back and front+back was smaller during the conditioning compared with the control (p < 0.05). No significant difference was found between sessions in a subgroup only demonstrating local pain (n = 9/24).

Conclusions

Engaging the descending noxious inhibitory control reduced the size of pain areas predominately when distinct pain referral was present. Assuming a conditioning effect of descending inhibitory control acting on dorsal horn neurons, these findings may indicate that mechanisms underlying pain referral can be modulated by endogenous control. The findings may indicate that referred pain may be a useful proxy to evaluate sensitivity of central pain mechanisms as previously suggested.

Significance

The current results indicate a link between endogenous inhibition and pain referral. Descending inhibitory control effects on pain referral support a spinal mechanism involved in pain referral. Future studies should investigate whether the spatial characteristics of referred pain (e.g. size, frequency of affected body regions and distribution away from the primary nociceptive stimulus) can useful to evaluate the efficiency of endogenous pain modulation.



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Amantadine prevented hypersensitivity and decreased oxidative stress by NMDA receptor antagonism after spinal cord injury in rats

Abstract

Background

Neuropathic pain (NP) after spinal cord injury (SCI) is a disabling condition, without an effective treatment. Hyperexcitability of N-methyl-D-aspartate (NMDA) receptors and oxidative stress have been reported to be associated with pain development. Amantadine, an NMDA receptor antagonist, has been proposed as a potential therapy for NP. However, its use has not been tested for NP after SCI.

Methods

To produce SCI, 120 female Wistar rats were used, a contusion injury to the T10 and T12 thoracic vertebrae was performed from heights of 6.25 mm and 12.5 mm. Nociceptive behaviour, was evaluated with the use of von Frey filaments for 31 days. The final products of lipid peroxidation (LP) and concentration of reduced glutathione (GSH) in the injured tissue were quantified by fluorescence spectrophotometry. The antinociceptive effect of the acute (15 days after the injury) and chronic (once daily for three days immediately after the injury) with amantadine (6.25–50 mg/Kg. I.p.) was determined. Finally, the LP and GSH were quantified in the injured tissue.

Results

Acute treatment with amantadine reduced nociceptive behaviour. Concomitantly, LP was decreased by Amantadine treatment while GSH increased in the injured tissue. Similar effects were observed with chronic treatment with amantadine.

Conclusions

Data from this study suggested that the antinociceptive effects of amantadine treatment are modulated through oxidative stress and excitotoxicity reduction associated with N-methyl-D-aspartate receptors activation.

Significance

This study suggests that acute treatment with amantadine decreases hypersensitivity threshold and frequency of hypersensitivity response in a dose-dependent manner, in rats with SCI, by decreasing oxidative stress. Since amantadine is an easily accessible drug and has fewer adverse effects than current treatments for hypersensitivity threshold and frequency of hypersensitivity response, amantadine could represent a safe and effective therapy for the treatment of neuropathic pain. However, further research is required to provide evidence of the effectiveness and feasibility.



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Antihypersensitivity effect of betanin (red beetroot extract) via modulation of microglial activation in a mouse model of neuropathic pain

Abstract

Background

Neuropathic pain (NeP) medications have several side effects that affect NeP patients' quality of life. Betanin, the most common betacyanin pigment, has been shown to have potent antioxidant and anti-inflammatory properties in vivo; thus, it has potential as a healthcare treatment. In this study, we focused on betanin (red beetroot extract) as a potential therapy for NeP.

Methods

Mice model of NeP were made by chronic constriction injury (CCI), and the development of mechanical hypersensitivity was confirmed using the von Frey test. Motor coordination and locomotor activity were assessed using open field tests and rotarod tests, respectively. The expression level of glial markers in the spinal cords was analyzed by immunostaining. The direct effects of betanin on microglial cells were investigated using primary cultured microglial cells.

Results

In CCI model mice, repeated betanin treatment, both intraperitoneally and orally, attenuated developing mechanical hypersensitivity in a dose-dependent manner without impairing motor coordination. Betanin treatment also attenuated mechanical hypersensitivity that had developed and prevented the onset of mechanical hypersensitivity in CCI mice. Microglial activation in the spinal cord is known to play a key role in the development of NeP; betanin treatment reduced CCI-induced microglial activation in the spinal cord of model mice. Moreover, in primary microglia cultured cells, the activation of microglia by lipopolysaccharide application was suppressed by betanin treatment.

Conclusion

Betanin treatment appears to ameliorate mechanical hypersensitivity related to CCI-induced NeP in mice by inhibiting microglial activation.

Significance

This article supports findings of the effect of betanin on NeP and provides a potential therapeutic candidate for NeP. Furthermore, elucidating the underlying mechanism of the effect of betanin on microglial activation could assist the development of new treatments for chronic pain.



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Anti‐nociceptive effects of oxytocin receptor modulation in healthy volunteers–A randomized, double‐blinded, placebo‐controlled study

Abstract

Background

There is increasing evidence for oxytocin as a neurotransmitter in spinal nociceptive processes. Hypothalamic oxytocinergic neurons project to the spinal dorsal horn, where they activate GABA-ergic inhibitory interneurons. The present study tested whether the long-acting oxytocin-analogue carbetocin has anti-nociceptive effects in multi-modal experimental pain in humans.

Methods

Twenty-five male volunteers received carbetocin 100 mcg and placebo (0.9% NaCl) on two different sessions in a randomized, double-blinded, cross-over design. Multi-modal quantitative sensory testing (QST) including a model of capsaicin-induced hyperalgesia and allodynia were performed at baseline and at 10, 60 and 120 min after drug administration. QST data were analysed using mixed linear and logistic regression models. Carbetocin plasma concentrations and oxytocin receptor genotypes were quantified and assessed in an exploratory fashion.

Results

An anti-nociceptive effect of carbetocin was observed on intramuscular electrical temporal summation (estimated difference: 1.26 mA, 95% CI 1.01 to 1.56 mA, p = .04) and single-stimulus electrical pain thresholds (estimated difference: 1.21 mA, 95% CI 1.0 to 1.47 mA, p = .05). Furthermore, the area of capsaicin-induced allodynia was reduced after carbetocin compared to placebo (estimated difference: −6.5 cm2, 95% CI −9.8 to −3.2 cm2, p < .001).

Conclusions

This study provides evidence of an anti-nociceptive effect of carbetocin on experimental pain in humans.

Significance

This study provides evidence of the anti-nociceptive effect of intravenous administration of the oxytocin agonist carbetocin in healthy male volunteers.



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Dissecting pain processing in adolescents with Non‐Suicidal Self Injury: Could suicide risk lurk among the electrodes?

Abstract

Background

Although non-suicidal self-injury (NSSI) disorder is highly prevalent in adolescents, its relationship with pain system function and suicidality is still controversial. The present study was designed to assess the function of the nociceptive afferent pathways and the endogenous pain modulation in adolescent patients with NSSI and to longitudinally register any suicide attempt, describe its frequency and find a possible association between suicide, neurophysiological measures and psychological measures.

Methods

We enrolled 30 adolescents suffering from NSSI and 20 age- and gender-matched healthy controls. Patients underwent a comprehensive psychological evaluation. Each participant underwent thermal pain thresholds of the quantitative sensory testing, laser-evoked potential recording to study the ascending nociceptive pathway and the conditioned pain modulation testing to test the endogenous pain modulation.

Results

We found that patients with NSSI had a reduced amplitude of the N2 component of laser-evoked potentials and an abnormal conditioned pain modulation. The amplitude of the N2 was associated with suicidal risk.

Conclusions

The deficit of the endogenous pain modulation likely depends on a saturation due to continuous pain solicitation. The strong association of a reduced amplitude of the N2 component with suicide suggests that it may serve as a possible biomarker in self-harming adolescents.

Significance

The present study identifies the N2 component of laser-evoked potentials as a possible neurophysiological biomarker of suicidal risk in patients with non-suicidal self-injury, therefore, raising the possibility for a non-invasive test to identify subjects at higher risk of suicide among self-harming patients.



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Seven‐year follow‐up of persistent postsurgical pain in cardiac surgery patients: A prospective observational study of prevalence and risk factors

Abstract

Background

Our aim was to describe the long-term prevalence, risk factors and impact on quality of life of persistent postsurgical pain (PPP) following cardiac surgery.

Methods

All patients undergoing sternotomy in a single centre over 6 months were prospectively interviewed by telephone at six months and seven years following surgery.

Results

We analysed data from 174 patients at six months and 146 patients at seven years following surgery, revealing a PPP prevalence of 39.7% (n = 69) and 9.6% (n = 14) respectively.

At six post-operative months, younger age, higher acute pain score, intraoperative remifentanil infusion and more prolonged surgery were associated with sternotomy-site PPP. These variables, in combination, predict PPP in this study group with area under the receiver operating curve of 0.91 (95% CI 0.86–0.94) at 6 months and 0.74 (95% CI 0.57–0.86) at 7 years. Quality of life scores were significantly lower with PPP (median change in EQ-5D score = −0.23 [−0.57, −0.09] compared to 0.00 [0–0.24] without PPP at 7 years, p < 0.001). At7 years, younger age, prolonged surgery and intraoperative remifentanil infusion were associated with sternotomy-site PPP.

Conclusions

To the best of our knowledge, this is the longest follow-up of PPP across all surgical specialities and certainly within cardiac surgery. Prevalence of PPP and impact on QOL after cardiac surgery are high and associated with young age, high acute pain score, use of remifentanil and long operative time. We present a predictive score to highlight patients at risk of developing PPP.

Significance

Seven years after cardiac surgery, almost 10% of patients in this cohort described persistent pain in and around the incision. While higher than previous reports in the literature (limited to up to five post-operative years), this assessment was made following three maximal coughs and therefore is movement or function evoked. High incident of persistent postsurgical pain may adversely affect long-term quality of life which is measured using a validated tool.



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High‐dose spironolactone lacks effectiveness in treatment of fibromyalgia (RCT)

Abstract

Background

Spironolactone (SPL) is a reversible mineralocorticoid receptor (MR) and androgen receptor (AR) antagonist which attracts pharmacotherapeutic interest not only because of its beneficial effects in heart failure but also because of the pathogenetic roles of MR and AR activities in neuropsychiatric diseases. Recently, beneficial and rapid-onset effects of SPL have been documented in a case series of women with fibromyalgia syndrome (FMS). To reaffirm this observation, we performed a double-blind placebo-controlled randomized clinical trial (RCT).

Methods

A total of 69 patients were screened, 56 patients were eligible and randomized to SPL or placebo (each n = 28). Forty-three patients completed the clinical trial to the last visit (n = 21 and n = 22). After a run-in phase of 50 and 100 mg/day, 200 mg/day SPL or placebo were applied between days 7 and 28. Primary outcome was the change in the FIQ-G score (Fibromyalgia Impact Questionnaire, German version). Secondary outcome parameters were the changes in pain (numeric rating scale, NRS), mood (ADS), quality of life (SF-36) and change in FIQ scores 14 days after the end of the medication.

Results

SPL of 200 mg/day did not change significantly either the primary or the secondary end points. SPL evoked a transient rise in serum potassium and a transient fall in GFR maximal after 2 weeks, but without clinical relevance.

Conclusions

SPL at 200 mg/day does not improve symptoms in women with FMS, but was considered not to cause harm.

Significance

The mineralocorticoid receptor and androgen receptor antagonist spironolactone is repeatedly tested for its therapeutic effectivity against neuropsychiatric disorders. The present RCT demonstrated that 200 mg spironolactone does not change the symptoms of the fibromyalgia syndrome (FMS) in adult women. Between 2 and 4 weeks, spironolactone evokes a transient decrease in GFR and increase in serum potassium. Spironolactone cannot be recommended for the treatment of FMS.



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Neck and shoulder pain in adolescents seldom occur alone: Results from the Norwegian Ungdata Survey

Abstract

Background

No previous studies have investigated the prevalence of co-occurring neck/shoulder pain, other musculoskeletal pain, headache and depressive symptoms in adolescents. This study aimed to describe the prevalence of isolated neck/shoulder pain and the co-occurrence of neck/shoulder pain with other musculoskeletal pain, headache and depressive symptoms in Norwegian adolescents.

Methods

This is a cross-sectional study using data from the Norwegian Ungdata survey (2017–2019). Adolescents from almost all municipalities in Norway answered a comprehensive questionnaire, including physical complaints. We investigated the prevalence of self-reported neck/shoulder pain in isolation and neck/shoulder pain in combination with other musculoskeletal pain, headache and depressive symptoms. The results were presented with per cent and stratified by school level and sex.

Results

In total, 253,968 adolescents (50% girls) participated in the study, of which 56.5% were from lower secondary school. The total prevalence of neck/shoulder pain was 24%, but only 5% reported isolated neck/shoulder pain. Among students reporting neck/shoulder pain, half of them also reported other musculoskeletal pain, and 50% of the boys and 70% of the girls reported co-occurring headache. Depressive symptoms were reported in 28% of the boys and 45% of the girls with neck/shoulder pain.

Conclusion

Neck/shoulder pain in adolescents is seldom isolated, but seems to co-occur with headache, other musculoskeletal pain and depressive symptoms. Researchers and clinicians should keep a broader health perspective in mind when approaching adolescents with neck/shoulder pain.

Significance

One in five adolescents reported neck/shoulder pain in this large population-based study of Norwegian adolescents. A majority of adolescents reported neck/shoulder pain in co-occurrence with other musculoskeletal pain, headache and depression. Researchers and clinicians should assess these comorbidities when assessing adolescents with neck/shoulder pain.



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Is Europe also facing an opioid crisis?—A survey of European Pain Federation chapters

Abstract

Background

There is considerable public interest in whether Europe is facing an opioid crisis comparable to the one in the United States and the contribution of opioid prescriptions for pain to a potential opioid crisis.

Methods

A task force of the European Pain Federation (EFIC) conducted a survey with its national chapter representatives on trends of opioid prescriptions and of drug-related emergency departments and substance use disorder treatment admissions and of deaths as proxies of opioid-related harms over the last 20 years.

Results

Data from 25 European countries were received. In most European countries opioid prescriptions increased from 2004 to 2016. The levels of opioid consumption and their increase differed between countries. Some Eastern European countries still have a low opioid consumption. Opioids are mainly prescribed for acute pain and chronic noncancer pain in some Western and Northern European countries. There was a parallel increase in opioid prescriptions and some proxies of opioid-related harms in France, Finland and the Netherlands, but not in Germany, Spain and Norway. In United Kingdom, opioid overdose deaths, but not opioid prescriptions increased between 2016 and 2018. There are no robust data available on whether prescribed opioids for pain patients contributed to opioid-related harms.

Conclusions

There are marked differences between European countries in trends of opioid prescribing and of proxies for opioid-related harms. Europe as a whole is not facing an opioid crisis. Discussions on the potential harms of opioids should not obstruct their prescription for cancer pain and palliative care.

Significance

Europe as a whole is not facing an opioid crisis. Some Eastern European countries have limited access to opioid medicines. Discussions on the potential harms of opioid medicines for noncancer pain should not obstruct opioid therapy for cancer therapy and palliative care.



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Perception of repeated pain relief with controllable and uncontrollable pain

Abstract

Background

The ultimate goal of pain research is to provide effective routes for pain relief. Nevertheless, the perception pain relief as a change in pain intensity and un-/pleasantness has only been rarely investigated. It has been demonstrated that pain relief has rewarding and reinforcing properties, but it remains unknown whether the perception of pain relief changes when pain reductions occur repeatedly. Further, it remains an open question whether the perception of pain relief depends on the controllability of the preceding pain.

Methods

In this study, healthy volunteers (N = 38) received five cycles of painful heat stimulation and reduction of this stimulation to a non-painful warm stimulation once in a condition with control of the stimulation and once without control. Participants rated perceived intensity and un-/pleasantness on visual analogue scales during the heat stimulation and immediately after its reduction.

Results

Results showed that perceived pain relief, estimated by the difference in ratings during ongoing heat stimulation and after its reduction, increased with repetitions. However, this increase levelled off after two to four repetitions. Further, perceived pain relief was larger in the condition without control compared to the condition with control.

Conclusion

The perception of pain relief can be modulated similar to the perception of pain by stimulus characteristics and psychological factors. Mechanistic knowledge about such modulating factors is important, because they can determine, e.g., the amount of requested pain killers in clinical settings and the efficacy of pain relief as a reinforcing stimulus.

Significance

When in pain, pain relief can become an all-dominate goal. The perception of such pain relief can vary depending on external and internal characteristics and thus modulate, e.g., requests for pain killers in clinical settings. Here, we show that perceived intensity and pleasantness of pain relief changes with repetitions and whether the preceding pain is perceived as uncontrollable. Such mechanistic knowledge needs to be considered to maximize the effects of pain relief as a rewarding and reinforcing stimulus.



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Synergism between oral paracetamol and nefopam in a murine model of postoperative pain

Abstract

Background

The use of paracetamol or nefopam for postoperative pain control is limited by the need of high doses associated with unwanted effects. Previous works suggest positive interactions between both compounds that may be exploited to obtain potentiation of antinociception.

Methods

Mechanical and heat antinociception induced by oral doses of paracetamol, nefopam or their combination was studied by isobolographic analysis in a murine model of postsurgical pain. The effective doses that produced 50% antinociception (ED50) were calculated from the log dose–response curves for each compound. Subsequently, the effects of ED8.7s, ED12.5s, ED17.5s and ED35s of nefopam and paracetamol combined were assessed.

Results

Oral paracetamol induced dose-dependent relief of postoperative sensitivity and showed higher efficacy reducing mechanical hypersensitivity (ED50 177.3 ± 15.4 mg/kg) than heat hyperalgesia (ED50 278.6 ± 43 mg/kg). Oral nefopam induced dose-dependent antinociception with similar efficacy for mechanical and heat hypersensitivity (ED50s 5.42 ± 0.81 vs. 5.83 ± 0.72). Combinations of increasing isoeffective doses revealed that combined ED17.5s (85.76 mg/kg paracetamol and 1.9 mg/kg nefopam) and ED35s (132.67 mg/kg and 3.73 mg/kg) showed synergistic effects leading to 75% and 90% mechanical antinociception, respectively. These mixtures were defined by interaction indexes of 0.43 and 0.41 and ratios 45:1 and 35:1 paracetamol:nefopam, respectively. The same combinations showed additive effects for the inhibition of incisional thermal hyperalgesia.

Conclusions and limitations

This work describes a synergistic antinociceptive interaction between low doses of nefopam and paracetamol for the treatment of postoperative hypersensitivity to peripheral stimuli. The promising results obtained on reflexive nociceptive responses of young male mice subjected to plantar surgery highlight the interest of further research evaluating the effects of this mixture on the affective-motivational component of pain and in females and additional age groups. Confirmation of pain-relieving efficacy and safety of this oral combination clinically available in European and Asian countries could provide a useful tool for postsurgical pain management.

Significance

Early postoperative pain is currently undertreated and has been recognized as a relevant source of chronic postsurgical pain. Oral efficient treatments could facilitate fast-track surgeries and patient recovery at home. Here, we identify in a mouse model of postoperative pain a potent synergistic oral combination consisting of low paracetamol and nefopam doses that provides relief of postsurgical hypersensitivity to mechanical and thermal stimuli. Oral multimodal paracetamol–nefopam mixtures represent a potential clinically available pharmacological strategy for the relief of incisional sensitivity and the promotion of patient recovery.



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Issue Information

European Journal of Pain, Volume 25, Issue 8, Page 1625-1626, September 2021.

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Self‐reported prognostic factors in adults reporting neck or low back pain: An umbrella review

Abstract

Background

Numerous systematic reviews have attempted to synthesize evidence on prognostic factors for predicting future outcomes such as pain, disability and return-to-work/work absence in neck and low back pain populations.

Databases and datatreatment

An umbrella review of systematic reviews was conducted to summarize the magnitude and quality of the evidence for each prognostic factor investigated. Searches were limited to the last 10 years (2008-11th April 2018, updated 28th September 2020). A two-stage approach was undertaken: in stage one, data on prognostic factors was extracted from systematic reviews identified from the systematic search that met the inclusion criteria. Where a prognostic factor was investigated in ≥1 systematic review and where 50% or more of those reviews found an association between the prognostic factor and one of the outcomes of interest, it was taken forward to stage two. In stage two, additional information extracted included the strength of association found, consistency of effects and risk of bias. The GRADE approach was used to grade confidence in the evidence.

Results

Stage one identified 41 reviews (90 prognostic factors), with 35 reviews (25 prognostic factors) taken forward to stage two. Seven prognostic factors (disability/activity limitation, mental health; pain intensity; pain severity; coping; expectation of outcome/recovery and fear-avoidance) were judged as having moderate confidence for robust findings.

Conclusions

Although there was conflicting evidence for the strength of association with outcome, these factors may be used for identifying vulnerable subgroups or people able to self-manage. Further research can investigate the impact of using such prognostic information on treatment/referral decisions and patient outcomes.



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Noninvasive management of soft tissue disorders of the shoulder: A clinical practice guideline from the Ontario Protocol for Traffic Injury Management (OPTIMa) collaboration

Abstract

Objectives

Objective of this study is to develop an evidence-based guideline for the noninvasive management of soft tissue disorders of the shoulder (shoulder pain), excluding major pathology.

Methods

This guideline is based on high-quality evidence from seven systematic reviews. Multidisciplinary experts considered the evidence of effectiveness, safety, cost-effectiveness, societal and ethical values, and patient experiences when formulating recommendations. Target audience is clinicians; target population is adults with shoulder pain.

Results

When managing patients with shoulder pain, clinicians should (a) rule out major structural or other pathologies as the cause of shoulder pain and reassure patients about the benign and self-limited nature of most soft tissue shoulder pain; (b) develop a care plan in partnership with the patient; (c) for shoulder pain of any duration, consider low-level laser therapy; multimodal care (heat/cold, joint mobilization, and range of motion exercise); cervicothoracic spine manipulation and mobilization for shoulder pain when associated pain or restricted movement of the cervicothoracic spine; or thoracic spine manipulation; (d) for shoulder pain >3-month duration, consider stretching and/or strengthening exercises; laser acupuncture; or general physician care (information, advice, and pharmacological pain management if necessary); (e) for shoulder pain with calcific tendinitis on imaging, consider shock-wave therapy; (f) for shoulder pain of any duration, do not offer ultrasound; taping; interferential current therapy; diacutaneous fibrolysis; soft tissue massage; or cervicothoracic spine manipulation and mobilization as an adjunct to exercise (i.e., range of motion, strengthening and stretching exercise) for pain between the neck and the elbow at rest or during movement of the arm; (g) for shoulder pain >3-month duration, do not offer shock-wave therapy; and (h) should reassess the patient's status at each visit for worsening of symptoms or new physical, mental, or psychological symptoms, or satisfactory recovery.

Conclusions

Our evidence-based guideline provides recommendations for non-invasive management of shoulder pain. The impact of the guideline in clinical practice requires further evaluation.

Significance

Shoulder pain of any duration can be effectively treated with laser therapy, multimodal care (i.e., heat/cold, joint mobilization, range of motion exercise), or cervicothoracic manipulation and mobilization. Shoulder pain (>3 months) can be effectively treated with exercises, laser acupuncture, or general physician care (information, advice, and pharmacological pain management if necessary).



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The effect of experimental and clinical musculoskeletal pain on spinal and supraspinal projections to motoneurons and motor unit properties in humans: A systematic review

Abstract

Background and Objective

Numerous studies have examined the influence of pain on spinal reflex excitability, motor unit behaviour and corticospinal excitability. Nevertheless, there are inconsistencies in the conclusions made. This systematic review sought to understand the effect of pain on spinal and supraspinal projections to motoneurons and motor unit properties by examining the influence of clinical or experimental pain on the following three domains: H-reflex, corticospinal excitability and motor unit properties.

Databases and Data Treatment

MeSH terms and preselected keywords relating to the H-reflex, motor evoked potentials and motor unit decomposition in chronic and experimental pain were used to perform a systematic literature search using Cumulative Index of Nursing and Allied Health Literature (CINAHL), Excerpta Medica dataBASE (EMBASE), Web of Science, Medline, Google Scholar and Scopus databases. Two independent reviewers screened papers for inclusion and assessed the methodological quality using a modified Downs and Black risk of bias tool; a narrative synthesis and three meta-analyses were performed.

Results

Sixty-one studies were included, and 17 different outcome variables were assessed across the three domains. Both experimental and clinical pain have no major influence on measures of the H-reflex, whereas experimental and clinical pain appeared to have differing effects on corticospinal excitability. Experimental pain consistently reduced motor unit discharge rate, a finding which was not consistent with data obtained from patients. The results indicate that when in tonic pain, induced via experimental pain models, inhibitory effects on motoneuron behaviour were evident. However, in chronic clinical pain populations, more varied responses were evident likely reflecting individual adaptations to chronic symptoms.

Significance

This is a comprehensive systematic review and meta-analysis which synthesizes evidence on the influence of pain on spinal and supraspinal projections to motoneurons and motor unit properties considering measures of the H-reflex, corticospinal excitability and motor unit behaviour. The H-reflex is largely not influenced by the presence of either clinical or experimental pain. Whilst inhibitory effects on corticospinal excitability and motor unit behaviour were evident under experimental pain conditions, more variable responses were observed for people with painful musculoskeletal disorders.



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Monday, August 9, 2021

Are mindfulness treatments effective for pain in cancer patients? A systematic review and meta‐analysis

Abstract

Mindfulness-based interventions (MBIs) have been recently applied in pain management and cancer care. However, inconsistencies exist concerning the effectiveness of MBIs on pain control among cancer patients. Therefore, this study aimed to examine the efficacy of MBIs on pain in cancer patients via a systematic review and meta-analysis of randomized controlled trials (RCTs). Databases (MEDLINE, PubMed, Embase, CINAHL, PsycINFO, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov) were searched using key terms related to pain, cancer, and mindfulness. The primary outcome was pain intensity. Standardized mean difference (SMD) of each outcome with 95% confidence interval (95% CI) was calculated. The quality of evidence was assessed by GRADE assessment. Ten RCTs with 843 participants were included. Significant pooled effects of MBIs on pain intensity were found at both short-term (SMD=-0.19, 95% CI [-0.33 to -0.04]) and long-term (SMD= -0.20, 95% CI [-0.35 to -0.05]) follow-up, whereas no significance was observed for pain interference. In subgroup analyses, significant intervention effects were only seen in clinic-based MBIs compared to remote MBIs, and pooled effects of MBIs in attenuating pain were discovered relative to passive rather than active comparators. GRADE ratings showed moderate certainty of evidence in MBIs for pain intensity but low for pain interference. The efficacy of MBIs in reducing pain intensity among cancer patients was revealed in this meta-analysis, albeit with a small effect size. Future research is warranted to optimize mindfulness treatment for pain control in cancer patients with high methodological quality and a large sample size.



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Comment on "Intrathecal dexmedetomidine and postoperative pain: A systematic review and meta‐analysis of randomized controlled trials"

Abstract

We had the great pleasure of reading the article titled "Intrathecal dexmedetomidine and postoperative pain: A systematic review and meta-analysis of randomized controlled trials" written by Paramasivan et al. The authors concluded that “the analgesic role of intrathecal dexmedetomidine is promising due to its ability to significantly increase postoperative analgesic duration when compared with placebo” (Paramasivan et al., 2020). At the outset, the authors should be congratulated for conducting a well-designed study and examining a very important topic in perioperative medicine. Nevertheless, we have several suggestions and queries that we would like to communicate with the authors.



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Are mindfulness treatments effective for pain in cancer patients? A systematic review and meta‐analysis

Abstract

Mindfulness-based interventions (MBIs) have been recently applied in pain management and cancer care. However, inconsistencies exist concerning the effectiveness of MBIs on pain control among cancer patients. Therefore, this study aimed to examine the efficacy of MBIs on pain in cancer patients via a systematic review and meta-analysis of randomized controlled trials (RCTs). Databases (MEDLINE, PubMed, Embase, CINAHL, PsycINFO, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov) were searched using key terms related to pain, cancer, and mindfulness. The primary outcome was pain intensity. Standardized mean difference (SMD) of each outcome with 95% confidence interval (95% CI) was calculated. The quality of evidence was assessed by GRADE assessment. Ten RCTs with 843 participants were included. Significant pooled effects of MBIs on pain intensity were found at both short-term (SMD=-0.19, 95% CI [-0.33 to -0.04]) and long-term (SMD= -0.20, 95% CI [-0.35 to -0.05]) follow-up, whereas no significance was observed for pain interference. In subgroup analyses, significant intervention effects were only seen in clinic-based MBIs compared to remote MBIs, and pooled effects of MBIs in attenuating pain were discovered relative to passive rather than active comparators. GRADE ratings showed moderate certainty of evidence in MBIs for pain intensity but low for pain interference. The efficacy of MBIs in reducing pain intensity among cancer patients was revealed in this meta-analysis, albeit with a small effect size. Future research is warranted to optimize mindfulness treatment for pain control in cancer patients with high methodological quality and a large sample size.



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Comment on "Intrathecal dexmedetomidine and postoperative pain: A systematic review and meta‐analysis of randomized controlled trials"

Abstract

We had the great pleasure of reading the article titled "Intrathecal dexmedetomidine and postoperative pain: A systematic review and meta-analysis of randomized controlled trials" written by Paramasivan et al. The authors concluded that “the analgesic role of intrathecal dexmedetomidine is promising due to its ability to significantly increase postoperative analgesic duration when compared with placebo” (Paramasivan et al., 2020). At the outset, the authors should be congratulated for conducting a well-designed study and examining a very important topic in perioperative medicine. Nevertheless, we have several suggestions and queries that we would like to communicate with the authors.



from Wiley: European Journal of Pain: Table of Contents https://ift.tt/3AiLokW
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Are mindfulness treatments effective for pain in cancer patients? A systematic review and meta‐analysis

Abstract

Mindfulness-based interventions (MBIs) have been recently applied in pain management and cancer care. However, inconsistencies exist concerning the effectiveness of MBIs on pain control among cancer patients. Therefore, this study aimed to examine the efficacy of MBIs on pain in cancer patients via a systematic review and meta-analysis of randomized controlled trials (RCTs). Databases (MEDLINE, PubMed, Embase, CINAHL, PsycINFO, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov) were searched using key terms related to pain, cancer, and mindfulness. The primary outcome was pain intensity. Standardized mean difference (SMD) of each outcome with 95% confidence interval (95% CI) was calculated. The quality of evidence was assessed by GRADE assessment. Ten RCTs with 843 participants were included. Significant pooled effects of MBIs on pain intensity were found at both short-term (SMD=-0.19, 95% CI [-0.33 to -0.04]) and long-term (SMD= -0.20, 95% CI [-0.35 to -0.05]) follow-up, whereas no significance was observed for pain interference. In subgroup analyses, significant intervention effects were only seen in clinic-based MBIs compared to remote MBIs, and pooled effects of MBIs in attenuating pain were discovered relative to passive rather than active comparators. GRADE ratings showed moderate certainty of evidence in MBIs for pain intensity but low for pain interference. The efficacy of MBIs in reducing pain intensity among cancer patients was revealed in this meta-analysis, albeit with a small effect size. Future research is warranted to optimize mindfulness treatment for pain control in cancer patients with high methodological quality and a large sample size.



from Wiley: European Journal of Pain: Table of Contents https://ift.tt/2U5bDff
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Comment on "Intrathecal dexmedetomidine and postoperative pain: A systematic review and meta‐analysis of randomized controlled trials"

Abstract

We had the great pleasure of reading the article titled "Intrathecal dexmedetomidine and postoperative pain: A systematic review and meta-analysis of randomized controlled trials" written by Paramasivan et al. The authors concluded that “the analgesic role of intrathecal dexmedetomidine is promising due to its ability to significantly increase postoperative analgesic duration when compared with placebo” (Paramasivan et al., 2020). At the outset, the authors should be congratulated for conducting a well-designed study and examining a very important topic in perioperative medicine. Nevertheless, we have several suggestions and queries that we would like to communicate with the authors.



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Pain modulates dopamine neurons via a spinal–parabrachial–mesencephalic circuit

Nature Neuroscience, Published online: 09 August 2021; doi:10.1038/s41593-021-00903-8

The authors identify a spinal–parabrachial–mesencephalic circuit that regulates the activity of dopamine neurons during pain.

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Sunday, August 8, 2021

Motor performance and back pain in children and adolescents: a systematic review

Abstract

Background and Objective

Motor performance during childhood and adolescence is recognized as a relevant determinant of present and future health, but its effects on back pain (BP) remain unclear. In this systematic review, we aimed to identify the association between motor performance and BP in children and adolescents.

Databases and Data Treatment

A literature search was performed in the MEDLINE, Scopus, Embase, SPORTDiscus, and CINAHL databases. We included cross-sectional, cohort, case-control, and controlled clinical trials (data from control groups). The inclusion criteria were as follows: (a) participants aged 6–19 years; (b) assessment motor performance components; (c) assessment of BP; and (d) reported measures of association. The risk of bias was assessed by the Downs and Black instrument and the quality of evidence by the grading of recommendations, assessment, development, and evaluation (GRADE).

Results

A total of 2,360 articles were identified, 25 of which were included in our systematic review. Of the 25 studies, 19 were evaluated as having a low risk of bias. GRADE indicated that 20 studies presented low or very low quality. Most of the studies evaluated flexibility (n=16), muscle endurance (n=18), and muscle strength (n=9). Aerobic capacity, balance, and speed were also examined in some studies (n<5). Overall, motor performance (flexibility, muscle endurance, muscle strength, aerobic capacity, balance, and speed) was not associated with BP. Most of the results were inconsistent because of the lack of studies, risk of bias, and low quality of evidence. Only trunk extensor muscle endurance was associated with decreased BP with moderate quality of the supporting evidence. Prospective studies with a low risk of bias are warranted to further clarify this relationship in childhood and adolescence and findings may support more targeted and effective health promotion interventions.



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Saturday, August 7, 2021

Pain relief reverses hippocampal abnormalities in trigeminal neuralgia

Chronic pain adversely affects cognitive performance and significantly impacts quality of life 58,63. Chronic pain patients frequently experience poor memory and concentration, often accompanied by increased anxiety and depression 3,8,14,15,23,35–37,40,57,64,66–68,74,75,82,85,90,102. The hippocampal formation consists of anatomically and functionally distinct subfields including the subiculum, Cornu Ammonis (CA1 – CA4), and dentate gyrus (DG). These subcortical regions play a significant role in memory formation 51, emotional processing, and stress modulation 103.

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Anger as a mechanism of injustice appraisals in pediatric chronic pain

Pain-related injustice appraisals focus on pain severity, irreparable loss, and blame and unfairness surrounding pain-related suffering [71]. These appraisals have been identified as an important cognitive-emotional factor in the pain experience of adults [12,40,41,59,64,72,73,74,77,90] and, more recently, children [2,17,46,47,48,49, Miller, 2019]. Pain-related injustice is associated with worse functioning for youth with chronic pain [2,17,46,47,48,49,Miller, 2019]. In a cross-sectional study by Miller and colleagues [47], pain-related injustice predicted unique variability in physical disability and emotional, social, and school functioning – over and above that of catastrophizing.

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Pupillary reflexes in complex regional pain syndrome: asymmetry to arousal stimuli suggests an ipsilateral locus coeruleus deficit

In complex regional pain syndrome (CRPS), the initial response to limb injury evolves into an intractably painful condition associated with sensory, autonomic, motor and trophic disturbances 5,41. Sensory disturbances often encompass much of the body, particularly on the affected side 10-12,15,39, possibly due to central sensitization and/or failure of inhibitory pain controls.

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Thursday, August 5, 2021

[Clinical Picture] Categorising myocardial infarction with advanced cardiovascular imaging

A 66-year-old man collapsed at home with chest pain. He was found by paramedics to be in ventricular fibrillation leading to a cardiac arrest. A post-resuscitation electrocardiogram showed sinus rhythm and inferolateral ST-segment elevation. On arrival at our department he had an emergency invasive coronary angiogram which showed an occluded left circumflex artery, confirming myocardial infarction (MI). We opened the artery using a balloon, and following recanalisation, we identified a substantial filling defect indicative of a large thrombus (figure).

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The ripples of trauma caused by severe pain during IUD procedures

Examples of excruciating pain experienced during the fitting of an intrauterine contraceptive device (also known as IUD or coil) have not been in short supply over the past month. After the release...


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Wednesday, August 4, 2021

Ward based management of behavioural and psychological symptoms of dementia

What you need to knowBehavioural and psychological symptoms of dementia (BPSD) can be exacerbated by a plethora of underlying reversible factors (eg, poor pain control) Identifying possible...


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Tuesday, August 3, 2021

Will Persistent Spinal Pain Syndrome replace Failed Back Surgery Syndrome?

Abstract

Failed back surgery syndrome (FBSS) is a stigmatizing and misleading term, and in many cases surgery is not relevant to the development, persistence, worsening or recurrence of the symptoms. An international panel recently proposed the notion of Persistent spinal pain syndrome (PSPS) as the preferred option to replace FBSS. The new label avoids ambiguity and inappropriately-implied causation. PSPS type 1 applies when there was no spinal surgery; type 2 applies when surgery had occurred. PSPS is therefore broader than FBSS but more accurate.



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Monday, August 2, 2021

Cross-national trends of chronic back pain in adolescents: results from the HBSC study, 2001-2014

Back pain is a common chronic pain problem in adolescents [20,22]. Moreover, back pain and chronic back pain in children and adolescents is associated with lower levels of well-being, higher medical care requirements and costs, and functional limitations [1,12,13,28,33,35]. A review of 27 systematic reviews on back pain in children and adolescents found that its monthly prevalence ranges from 18% to 24%. In most, but not all, of the reviews, the prevalence of back pain was higher for girls than boys, and increased with age [23].

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