Hyaluronan (HA), a negatively charged linear disaccharide polymer, is an integral component of the extracellular matrix 44,46 that plays a role in several physiological processes. High molecular weight hyaluronan (HMWH) has been used extensively to treat osteoarthritis pain 3,16,19,29,47 and has been shown to have anti-inflammatory and immunosuppressive effects 17,25,30,34,51. We have shown that HMWH is anti-hyperalgesic against several pro-inflammatory mediators and in chemotherapy-induced neuropathic pain 10,21,23.
from The Journal of Pain https://ift.tt/2QFvf7q
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