Chronic musculoskeletal pain is a major health problem with a one-year prevalence of 25% to 36% in the general population35. Costs related to persistent pain in the United States of America are between $560 and $635 billion annually18. Many persistent pain states are not associated with ongoing tissue pathology, an originally perplexing observation that is now explained by functional changes in the nociceptive system and brain79-81. Broadly speaking, these functional changes may be considered learning; stimulus-response profiles change such that stimuli that are not normally painful come to evoke pain, a situation termed allodynia, and normally painful stimuli come to evoke more pain, a situation termed hyperalgesia79.
from The Journal of Pain https://ift.tt/2YpLHJK
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