Ongoing enhanced pain sensitivity (hyperalgesia) is a common feature in chronic low back pain (LBP).100,125 Multiple mechanisms contribute to this form of hyperalgesia, most of which involve neural changes that alter processing of nociceptive information.6,62,127 These changes can arise quickly or develop over time in response to “peripheral” or “central” processes that increase neuronal excitability within the central nervous system (CNS). Peripherally, inflammatory agents (e.g., cytokines) in post-injury tissue enhance nociceptor sensitivity, which is called peripheral sensitisation.
from The Journal of Pain https://ift.tt/2Hlhrsj
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