Total Western Diet (TWD) alters mechanical and thermal sensitivity and prolongs hypersensitivity following Complete Freund’s Adjuvant in mice

Obesity and chronic pain are often comorbid and their rates are rising. It is currently unknown whether increased pain is due to greater weight or poor diet quality, or both. Therefore, we utilized a Total Western Diet (TWD) to investigate the functional and physiological consequences of nutritionally-poor diet in mice. During thirteen weeks on the commercially-available TWD, based on the National Health and Nutrition Examination Survey (NHANES), thresholds of TWD-fed mice significantly increased in both thermal and mechanical tests.

from The Journal of Pain http://ift.tt/1R50zkV
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