The use of rodents in preclinical studies has contributed greatly to our understanding of the pathophysiology of chronic neuropathic pain. Unfortunately, these animal models are somewhat limited due to their poor clinical translation. We developed a pig model for chronic pain caused by surgically-induced peripheral neuritis trauma (PNT). Seventy five percent of the animals exhibited mechanical and tactile allodynia, which are indicative of painful neuropathy, by day 28 post-surgery. Importantly, the PNT-injured pigs retained their ability to walk or to stand on their injured leg.
from The Journal of Pain http://ift.tt/1Q6ikA6
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