Chronic back pain (CBP) is associated with circumscribed atrophy in gray matter (GM) predominantly localized in areas of the so called “pain matrix” and the prefrontal cortex (PFC). Previous studies applying voxel-based morphometry (VBM) for identifying structural brain alterations related to CBP have reported inconsistent results, are limited to small sample sizes and often did not control for medication. We therefore used VBM for high resolution magnetic resonance images to investigate the association of CBP and regional GM volume in 111 individuals with CBP und 432 pain free controls derived from the representative Study of Health in Pomerania (SHIP), while controlling for effects of medication.
from The Journal of Pain http://ift.tt/1jBly3W
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