Itch and pain are unpleasant sensations that distress patients from many diseases. However, most previous studies have focused on the neural mechanisms of pain, and much less effort has been devoted to itch. It has been reported that itch and pain might share a common pathway, and GABAA receptors in the central nucleus of the amygdala (CeA) are involved in pain modulation. However, the contribution of GABAA receptors in the CeA to the modulation of itch remains poorly understood. Here, we reported that bilateral intra-CeA microinjection of a selective GABAA receptor agonist muscimol (50 ng/side), but not a selective GABAA receptor antagonist bicuculline (20 ng/side) or vehicle, displayed significantly analgesic effects, as reflected by an increase in tail-flick latency and a decrease in allyl isothiocyanate (AITC; mustard oil)-evoked ipsilateral forelimb wipes.
from The Journal of Pain http://ift.tt/1O8OIon
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