Sickle cell disease (SCD) is a hemoglobinopathy affecting more than 100,000 individuals in United States. The disease is characterized by presence of sickle hemoglobin and recurrent episodes of pain. Some individuals with SCD experience frequent hospitalizations and high burden of pain. The role of central mechanisms in SCD pain has not been explored. Twenty-five adolescents and young adults with SCD underwent functional MRI (fMRI). Participants were stratified into high or low pain groups based on the number of hospitalizations for pain in preceding 12 months.
from The Journal of Pain http://ift.tt/1Myszib
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