Interferons (IFNs) are a class of cytokines originally detected in immunological cells, but have since been shown to be produced during non-immunological responses of both central and peripheral origins. IFNs regulate antiviral and immunomodulatory responses as well as cell growth in immune cells (lymphocytes and macrophages) and non-immune target cells from epithelial and nervous tissues.10,12,34,61,62 There are two major types of IFNs: type I consists chiefly of IFNα and IFNβ, and also IFNω, IFNδ, and IFNτ, whereas type II consists of a single type, IFNγ.
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