Usefulness of Ramp & Hold Procedures for Testing of Pain Facilitation in Human Participants: Comparisons with Temporal Summation of Second Pain

Quantitative sensory testing (QST) is often used for the study of sensory function including pain mechanisms in basic and clinical research. QST methods range from simple threshold testing to complex multi-modal test procedures of hyperalgesia, allodynia, and pain modulation (spatial and temporal).39 The application of precise experimental pain stimuli has been used extensively for the evaluation of pain mechanisms in animals6,11,25,55 and humans16,39,50 with help of mechanical, thermal, and electrical stimuli.

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