Saturday, May 11, 2019

Suppression of WNK1-SPAK/OSR1 attenuates bone cancer pain by regulating NKCC1 and KCC2

Bone cancer pain (BCP), the most common symptom of the patients with primary or metastatic bone cancer, affects approximately one third of cancer patients.6,9 This type of pain is often severe and substantially hampers patients’ quality of life.11,30,34 Unfortunately, treatment for BCP still remains a major challenge due to the lack of understanding of underlying mechanisms.

from The Journal of Pain http://bit.ly/2WLqXti
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