Pharmacological Inhibition of Porcupine, Disheveled and β-catenin in Wnt Signaling Pathway Ameliorates Diabetic Peripheral Neuropathy in Rats

Type 1 diabetes is often associated with many co-morbid complications, out of which, diabetic peripheral neuropathy (DPN), stands out to be one of the most common one, across the globe, affecting almost 50-60% of diabetic patients worldwide.8,53 DPN manifests as sensory symptoms in a distal ‘glove-and-stocking’ distribution, thereby causing a debilitating pain in the form of parasthesias, hyperalgesia and allodynia.15,45 Hyperglycemia, the characteristic feature of Type 1 diabetes long been thought to instigate DPN pathology, either through direct neurotoxicity, or from the activation of secondary pathways.

from The Journal of Pain http://bit.ly/2LvaSqz
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