Data from rodents and humans indicate that activation of peripheral nicotinic acetylcholine receptors (nAChRs) can be either pro- or antinociceptive. Application of nicotine at a variety of superficial and deep tissue sites evokes the sensation of pain in humans7,17 and nociceptive responses in the rat.4,29 Persistent inflammation is associated with increased α3β4 subunit expression3 and an increase in nAChR current density in putative nociceptive DRG neurons.35 Furthermore, inflammatory hypersensitivity appears to be due, at least in part, to nAChR activation.
from The Journal of Pain http://bit.ly/2FHFukp
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