It is widely accepted that neuroinflammation in the spinal cord plays an important role in the development of central sensitization in neuropathic pain. Spinal MAPKs activation contribute to the development of neurinflammation in neuropathic pain.13,15 However, Ndong C et al reported that mitogen-activated protein kinase phosphatase 1(MKP-1), a negative feedback of activated MAPKs, was reduced in the development of neuropathic pain.27 Upregulation of spinal MPK-1 alleviated the behavioral hypersensitivity in neuropathic pain.
from The Journal of Pain http://bit.ly/2Mf3XhY
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