• Infraorbital nerve injury (dIoN-CCI) induced trigeminal neuropathic pain (TNP).• HCN1 and HCN2 were the major HCN isoforms in the gasserian ganglion (GG).• Inhibition of HCN channel activity in the GG ameliorated TNP.• HCN blocker ivabradine showed a prolonged analgesic effect.• HCN1 and HCN2 expression was increased in the GG after dIoN-CCI.
from The Journal of Pain http://ift.tt/2mYU63w
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