The relationship between adverse life events and endogenous inhibition of pain and spinal nociception: Findings from the Oklahoma Study of Native American Pain Risk (OK-SNAP)

Accumulating evidence suggests a dose-dependent relationship between ALEs and myriad negative sequalae, including sleep disturbances1, immune dysregulation31, somatic problems1, lower quality of life1, and psychopathology17. ALEs are also considered to be a risk factor for chronic pain52,70, yet few proximate mechanisms have been identified to explain the link. Nonetheless, the cumulative number of ALEs is associated with pain risk above and beyond the severity and magnitude of each individual event67,70.

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