Prevalence and interference of chronic pain among people with haemophilia: A systematic review and meta-analysis

Haemophilia is an X-linked rare congenital bleeding disorder, characterized by a deficiency in blood clotting factor VIII (haemophilia A) or IX (haemophilia B). As a consequence, the main clinical manifestation of the disease are spontaneous bleeding episodes that most frequently occur in the joints and muscles28,41. Haemophilia severity is graded according to plasma levels of clotting factor activity as mild (5–40% of normal), moderate (1–5% of normal) or severe (<1% of normal), and is generally associated with a corresponding increase in bleeding frequency3.

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