The underlying neurobiological and behavioral modifications needed to promote healing of an organism provide an empirical framework for understanding normal and pathological pain states. At a minimum, there is a dualistic modulation of pain sensitivity to promote resumption of physical activity yet prevent tissue re-injury. Throughout the post-injury persistent pain state, opponent neural processes participate in modulation of a sensory set-point to balance acute and tonic incoming nociceptive information to control resolution of the hyperalgesic state as the organism heals.
from The Journal of Pain https://ift.tt/2QF5SCO
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