Chronic pain is a common clinical syndrome that has significant negative effects on quality of life and leads to enormous social and economic problems, and among chronic pain conditions orofacial pain can be the most severe and debilitating.41,50 Such pain can derive from orofacial inflammation and tissue and nerve injuries and is characterized by primary mechanical hyperalgesia (hypersensitivity at the site of injury) and secondary mechanical hyperalgesia (extra-territorial hypersensitivity outside the injured zone).
from The Journal of Pain https://ift.tt/2LkXS4N
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