The central nervous system plays an imperative role in pain processing, and can undergo neuro-plastic changes in response to pain.3,38,42,97,111 The neuro-matrix of pain theory proposed a neural signature of brain networks uniquely responsible for pain processing.81 However, in the last decades this ‘pain matrix’ was questioned as studies showed that involved brain areas are not solely responsible for pain processing, but also for non-painful salient stimuli.70,88,104,120 The main consequence of the introduction of the ‘pain matrix’ is that research regarding pain processing shifted from the peripheral to the central nervous system.
from The Journal of Pain https://ift.tt/2Xcgvum
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