A Novel Mu-Delta Opioid Agonist Demonstrates Enhanced Efficacy with Reduced Tolerance and Dependence in Mouse Neuropathic Pain Models

Pharmacological studies over the past few decades have demonstrated physiological interactions between the mu opioid receptor (MOR) and delta opioid receptor (DOR) systems. Inhibition of the DOR by various means had the effect of reducing MOR-mediated side effects like tolerance and dependence.1,44,51 Numerous other studies have shown altered activity of MOR- and DOR-selective ligands when the reciprocal receptor is inhibited.29,35 It is thus clear that the MOR and DOR systems extensively modulate each other, but the mechanisms are not known.

from The Journal of Pain http://bit.ly/2F79HYM
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