Complex regional pain syndrome (CRPS) affects about 7% of patients after limb trauma4 and leads to chronic pain in the affected limb. There is growing evidence for a pathophysiological involvement of the central nervous system in maintaining CRPS symptoms by altered central sensorimotor processing22,53 and pathological cortical reorganization31,32,43. In addition, neuropsychological pathologies have been described in CRPS, such as impairment in integrating objects spatially in reference to the own body, and a neglect-like mechanism has been controversially discussed36,56.
from The Journal of Pain http://bit.ly/2G3imOj
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