Thursday, March 4, 2021

P2X4R contributes to central disinhibition via TNF-α/TNFR1/GABAaR pathway in post-stroke pain rats

Stroke is the leading cause of adult disability worldwide41. Central post-stroke pain (CPSP) is a chronic neuropathic pain, which is one of the most difficult sequelae of ischemic and hemorrhagic stroke11. This syndrome is characterized by spontaneous or an abnormal sensation secondary to noxious or non-noxious stimuli including spontaneous pain, hyperalgesia, and allodynia17, which localize at one of multiple sites in the somatosensory pathway27. Thalamus stroke is one of the major causes of neuropathic central pain.

from The Journal of Pain https://ift.tt/30cQOhe
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