Fibromyalgia (FM) is characterized by widespread chronic pain, insomnia, fatigue, and memory problems. It also has been associated with hypersensitivity to painful stimuli. Much of the evidence for such abnormalities has come from quantitative sensory testing (QST) of heat, pressure, electrical current, and chemical sensitivity which all depend on spinal cord modulation before transmission to the brain 30. The increased sensitivity of FM patients to noxious peripheral stimuli has been explained by central sensitization of dorsal horn neurons, based on evidence of wide-spread secondary hyperalgesia and abnormal temporal pain summation 12, 65, 66, 69.
from The Journal of Pain https://ift.tt/3aMjR1u
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