Imaging studies link migraine pathophysiology to functional abnormalities in pain modulatory brain areas.57,75 When interictal migraineurs are exposed to evoked pain, the pain-modulatory areas become hyperactive, and the level of hyperactivity is associated with attack frequency and pain intensity.56,63,81,96 Migraineurs also exhibit an association between migraine clinical characteristics, and altered resting-state functional connectivity (rsFC) of mesencephalic, cingulate, insular and prefrontal brain areas involved in affective processing and descending inhibition of pain.
from The Journal of Pain https://ift.tt/35gfWDN
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