Neuropathic pain is a very common clinical disorder, usually caused by nerve injury or accompanying some diseases (such as diabetes). It reduces the quality of life in patients due to a lack of effective analgesic strategies. The altered gene/protein expression in primary sensory neurons following injury has been demonstrated as the key component of the pathophysiology of neuropathic pain 16,17,29,40,41. A next generation RNA sequencing analysis revealed the differential expression of thousands of genes in the injured DRG caused by spinal nerve ligation (SNL) 35.
from The Journal of Pain https://ift.tt/2FoTZbt
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