Occupational vibration exposure produces a condition characterized by musculoskeletal, neurological and vascular pathology, referred to as hand-arm vibration syndrome (HAVS).31 This condition affects up to 50% of workers who use handheld power tools such as jackhammers, pneumatic chipping and grinding mechanical tools.36 One of the most problematic symptoms of HAVS is persistent muscle pain, which can be extremely disabling and resistant to treatment.13,14,31 We have developed a preclinical model of HAVS in the rat that displays persistent mechanical hyperalgesia in the gastrocnemius muscle, mediated by pro-inflammatory cytokines, interleukin (IL) 6 and tumor necrosis alpha (TNFα).
from The Journal of Pain https://ift.tt/2lAGqzn
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