• Opioid antinociceptive and behaviorally disruptive effects are measured concurrently.• The ratio of ED50 values for both measures are calculated, and differ among opioids.• These ratios indicate the behavioral selectivity of opioid antinociception.• ED50 ratios serve as preclinical estimates of therapeutic index.• Opioids with differing ED50 ratios may have differing scopes of clinical utility.
from The Journal of Pain http://ift.tt/2BLRoYz
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