Opposite associations between the rs3845446 single-nucleotide polymorphism of the CACNA1E gene and postoperative pain-related phenotypes in gastrointestinal surgery versus previously reported orthognathic surgery

Perspective: Carriers of the minor allele of the rs3845446 single-nucleotide polymorphism of the CACNA1E gene required more opioid or reported higher pain scores after gastrointestinal surgery, while requiring less opioid after orthognathic surgery. The difference may result from the presence of visceral inflammatory pain stimulus that activates Cav2.3 voltage-activated Ca2+ channels-mediated antinociception.

from The Journal of Pain http://ift.tt/2a646Vn
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