Repetitive acupoint treatment with diluted bee venom relieves mechanical allodynia and restores intraepidermal nerve fiber loss in oxaliplatin-induced neuropathic mice

We demonstrate that repetitive acupoint stimulation with DBV gradually and significantly reduces oxaliplatin-induced mechanical allodynia and restores the loss of IENFs in neuropathic mice via an alpha-2 adrenoceptor mechanism. Collectively this study suggests that repetitive acupoint treatment with DBV can be a potential strategy for the management of chemotherapy-induced neuropathy.

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