Ginsenoside-Rb1 (Rb1) has anti-inflammatory effects. However, the potential anti-nociceptive value of Rb1 for the treatment of acute inflammatory nociception is still unknown. Here, we examined whether Rb1 has any anti-nociceptive effects on acute inflammatory nociception in Sprague Dawley rats given intrathecal (i.t.) introduction of Rb1 (2, 10, and 50 μg) 20 minutes before injection of formalin (5%, 50 μl) into the plantar surface of the hind paws. I.t. introduction with Rb1 significantly decreased nociceptive behavior during phase II (16-60 minutes), but not phase I (0-10 minutes), after formalin stimulation, corresponding to the reduced activation of c-Fos in the L4-L5 spinal dorsal horn after formalin stimulation.
from The Journal of Pain http://ift.tt/1WADbTk
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