There is little information regarding changes in placebo responsiveness with age although first predictors of placebo responders such as psychological and physiological processes have been identified.Reviews and meta-analyses indicate that placebo response rates in RCTs are higher in children and adolescents compared to adults. As these studies cannot control for age-dependent differences in the natural course of the disease, biases might contribute to different placebo rates in RCTs. To avoid these biases, this study investigated age-related differences in placebo responsiveness between children and adults in a well-established experimental model of placebo analgesia combining classical conditioning and expectation.
from The Journal of Pain http://ift.tt/1S2aAnG
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