Slowing in peak-alpha frequency recorded after experimentally-induced muscle pain is not significantly different between high and low pain-sensitive subjects

Acute muscle pain serves an important protective function in preventing or limiting muscle damage. However, often in chronic musculoskeletal pain conditions, muscle pain no longer serves protective functions but may be associated with abnormal brain responses24,55. Functional and structural brain imaging studies have recently demonstrated that increased perception of chronic musculoskeletal pain is associated with altered activity of neural networks3,4 and grey matter thickness of several cortical regions1,52.

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