Neuropathic pain is a common maladaptive disorder produced by injuries of the nervous system. It is reflected by presenting pain under non-painful stimulus (allodynia), increased pain after painful stimulus (hyperalgesia) and spontaneous pain without stimuli. Neuropathic pain is considered the result of neural plasticity, produced by an increase in the excitability of primary sensory neurons and nociceptive neurons in the spinal cord and the brain26;52. A critical contributor to neuronal excitability, and thus to the induction and maintenance of neuropathic pain, are microglial cells, together with blood borne macrophages33.
from The Journal of Pain https://ift.tt/3vHfUlR
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