Effects of vancomycin on persistent pain-stimulated and pain-depressed behaviors in female Fischer rats with or without voluntary access to running wheels

The gut microbiome is implicated in health and the pathogenesis of disease states, including neuroinflammation and intestinal inflammatory pain 36,61. Modulation of the gut microbiome is possible via a wide variety of procedures that include antibiotic intervention and fecal microbiota transplantation (FMT). An example of the former strategy is administration of narrow- or broad-spectrum antibiotics with the goal of selective or global depletion of specific taxa, and the latter strategy of FMT from healthy donors, allows for replenishment of these bacteria in recipient hosts 2,57,60,74.

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