Advancements in the understanding and treatment of complex chronic pain syndromes using preclinical models and conventional clinical approaches have failed to provide relief for a significant number of affected individuals worldwide. Provoked vestibulodynia (PVD) which affects up to 16% of women is one such disorder, which is characterized by local vestibular hypersensitivity and severe pain with vaginal penetration.11 Similar to many other chronic pain conditions and providing evidence for central sensitization, PVD has been consistently linked to symptom-associated changes in brain structure and function, particularly in regions involved in pain processing and modulation (e.g., sensorimotor cortex, thalamus, amygdala, hippocampus, basal ganglia, brainstem).
from The Journal of Pain https://ift.tt/3wp68Fz
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