The transient receptor potential V1 (TRPV1) is a non-selective cation channel activated by heat and capsaicin, the pungent ingredient contained in hot chili peppers.35 TRPV1 is expressed in the majority of polymodal nociceptors (thinly myelinated Aδ and unmyelinated C-fibers)3,7,50 involved in the transduction of nociceptive and pruritic signals and in the pathophysiology of neuropathic pain.1 Initially, the activation of TRPV1 by capsaicin induces an influx of Ca2+ and Na+ ions resulting in depolarization and thereby generating an action potential.
from The Journal of Pain https://ift.tt/36onszT
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