A role for protease activated receptor type 3 (PAR3) in nociception demonstrated through development of a novel peptide agonist

Protease activated receptor 3 (PAR3) belongs to the PAR family of G-protein coupled receptors (GPCRs), a group of receptors expressed in many cell types and implicated in a variety of inflammatory pathologies 11, 26, 28, 56. Like the other PARs, PAR3 does not have an endogenously present ligand but rather is activated through extracellular cleavage of the N-terminal end via proteases. After proteolytic cleavage, the newly available tethered ligand can bind to the receptor, initiating multiple downstream signaling cascades 51.

from The Journal of Pain https://ift.tt/2MEwnGs
via IFTTT