A Systematic Review into the Influence of Temperature on Fibromyalgia Pain: Meteorological Studies and Quantitative Sensory Testing

Fibromyalgia syndrome (FMS) is a chronic widespread pain condition of uncertain aetiology and may be viewed as pain state with central amplification13, 14, 74. However, there is also mounting evidence of peripheral abnormalities including small fibre polyneuropathy with abnormal nociceptor function25, 33, 51, 73, abnormal thermoregulatory peripheral innervations1, and even peripherally binding pain-sensitising IgG autoantibodies31. FMS is characterised by widespread pain and a constellation of other symptoms, most markedly fatigue, sleep disturbance and cognitive problems14, 90.

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