Systematic review and meta-analysis of genetic risk of developing chronic postsurgical pain

Chronic post-surgical pain (CPSP) is an important clinical problem of considerable magnitude, that negatively affects recovery after surgery. The initial criteria proposed by Macrae and Davies55 in 1999, and modified by Werner and Kongsgaard89 define CPSP as 1) pain that develops after a surgical procedure or increases in intensity after the surgical procedure, 2) pain of at least 3–6 months’ duration and significantly affects quality of life, 3) pain that is a continuation of acute post-surgery pain or develops after an asymptomatic period, 4) pain localized to the surgical field, projected to the innervation territory of a nerve situated in the surgical field, or referred to a dermatome, and 5) other causes of the pain should be excluded.

from The Journal of Pain http://bit.ly/2YJo9h4
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