Chronic pain has been found to be associated with structural and functional changes in the regions of the brain that are involved in the cognitive and emotional modulation of pain. These neurological changes contribute to the maintenance of pain, creating a vicious self-perpetuating circle. Evidence of these neurological changes has been found in several chronic pain syndromes1,21,29,37,46,77,79; however, endometriosis-related pelvic pain was still not comprehensively studied in this context. Endometriosis is a gynecologic condition that affects up to 15% of reproductive-aged women worldwide, constituting the most common cause of chronic pelvic pain (CPP)22,33,92 in this population.
from The Journal of Pain http://bit.ly/2YZ3o0O
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