Sessions of prolonged continuous theta burst stimulation or high-frequency 10 Hz stimulation to left dorsolateral prefrontal cortex for three days decreased pain sensitivity by modulation of the efficacy of conditioned pain modulation

Non-invasive brain stimulation has received a lot of attention as a potential pain therapy.25,35 For instance, 10Hz repetitive transcranial magnetic stimulation (rTMS) applied to the left dorsolateral prefrontal cortex (L-DLPFC) decreased pain sensitivity in healthy subjects13,62 and reduced experimental,56,61,62 post-operative,9,10,14 and chronic pain.12,45,57 Although several studies demonstrated pain relief effects of daily 10Hz L-DLPFC rTMS sessions in chronic12,45,57 and in experimental pain,56 no studies have proven whether the decreased pain sensitivity in healthy subjects could be maintained for several hours by repetitive sessions of rTMS, which may have a clinical relevance if one considers rTMS to be potentially useful before painful procedures.

from The Journal of Pain http://bit.ly/2M9hiw7
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