North America is amid an opioid crisis, which has its roots in opioid prescribing for non-cancer pain.37 Each year, 1 in 7 Canadians take a prescribed opioid on the advice of their physician,59 a rate second only to the United States in highest prescribing worldwide.36 In the United States, 2.4 million people meet the criteria for severe opioid use disorder (OUD) involving dependence on opioid analgesic medications, heroin, or both.37 These high levels of opioid use have led to many problems, including an increase in reported opioid misuse,7 illicit opioid use,35 overdoses and death,4,19 drug diversion, and crime,4,5,23 along with a substantial economic impact.
from The Journal of Pain http://bit.ly/2GUedtY
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