Amputation is adopted to save life at the sacrifice of a part of the body in the clinical cases where no existing alternatives could be taken. However, amputation may lead to postamputation pain (PAP) and the pain management is challenging in clinical practice16. Similar to other neuropathic pain conditions, the pathophysiological mechanisms of PAP are complicated and remain to be elucidated, given that multiple levels of nervous system might be involved, ascending from injured peripheral nerve, dorsal root ganglion, to spinal cord dorsal horn and supraspinal regions7,17,31.
from The Journal of Pain http://bit.ly/2VGkcst
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