Pre-clinical research has identified numerous mechanisms for neuropathic pain that can be targeted by drugs for pain relief in patients,11 but most novel compounds have failed as clinically useful analgesics.33 These failures emphasize the extent of the difficulties translating drug efficacy from animal models to patients.38 To aid clinical translation, early phase studies may involve testing of potentially analgesic compounds in healthy human volunteers. Such studies involve the induction of symptoms that are relevant to peripheral or central sensitization, against which the potential of an analgesic can be assessed.
from The Journal of Pain http://bit.ly/2Pic7Ib
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