Desmetramadol has the Safety and Analgesic Profile of Tramadol Without Its Metabolic Liabilities: Consecutive Randomized, Double-Blind, Placebo- and Active Comparator-Controlled Trials

It has been recommended that the morphine milligram equivalent dose in patients receiving opioid therapy be reduced in order to reduce opioid-related overdose and death.15, 20, 30 There are unfortunately limited pharmacologic options for patients seeking an alternative to schedule II opioids who still require effective analgesia. A critical challenge therefore exists to identify analgesic options for those suffering from pain that are safer and reduce the risk of treatment-related death.

from The Journal of Pain http://bit.ly/2v9hXlL
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