Tropomyosin receptor kinase B receptor activation in the locus coeruleus restores impairment of endogenous analgesia at a late stage following nerve injury in rats

Insufficient endogenous analgesia is reported in human patients with various types of chronic pain.3,10,13,22,25,29 Endogenous analgesia in humans can be evaluated by measuring conditioned pain modulation.41 In experimental animals, conditioned pain modulation is assessed based on noxious stimuli-induced analgesia (NSIA).28 The noxious stimulus in NSIA is a subcutaneous injection of capsaicin, and the resulting endogenous analgesia is heterosegmental, i.e., antinociception can be observed at sites remote from the site of stimulation.

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